As COVID-19 cases, deaths and fatality rates surge in Italy, underlying causes require investigation.
Identifieur interne : 000978 ( Main/Exploration ); précédent : 000977; suivant : 000979As COVID-19 cases, deaths and fatality rates surge in Italy, underlying causes require investigation.
Auteurs : Salvatore Rubino [Italie] ; Nikki Kelvin [Canada] ; Jesús F. Bermejo-Martin [Espagne] ; David Kelvin [Canada]Source :
- Journal of infection in developing countries [ 1972-2680 ] ; 2020.
Descripteurs français
- KwdFr :
- Accessibilité des services de santé, Anticorps antiviraux, Chine (épidémiologie), Humains, Immunité acquise, Infections à coronavirus (diagnostic), Infections à coronavirus (mortalité), Italie (épidémiologie), Mortalité, Pandémies, Pneumopathie virale (diagnostic), Pneumopathie virale (mortalité), Reproductibilité des résultats, Techniques de laboratoire clinique, Épidémiosurveillance, Études séroépidémiologiques.
- MESH :
- diagnostic : Infections à coronavirus, Pneumopathie virale.
- mortalité : Infections à coronavirus, Pneumopathie virale.
- épidémiologie : Chine, Italie.
- Accessibilité des services de santé, Anticorps antiviraux, Humains, Immunité acquise, Mortalité, Pandémies, Reproductibilité des résultats, Techniques de laboratoire clinique, Épidémiosurveillance, Études séroépidémiologiques.
- Wicri :
- geographic : République populaire de Chine, Italie.
English descriptors
- KwdEn :
- Adaptive Immunity, Antibodies, Viral, Betacoronavirus (immunology), Betacoronavirus (pathogenicity), China (epidemiology), Clinical Laboratory Techniques, Coronavirus Infections (diagnosis), Coronavirus Infections (mortality), Epidemiological Monitoring, Health Services Accessibility, Humans, Italy (epidemiology), Mortality, Pandemics, Pneumonia, Viral (diagnosis), Pneumonia, Viral (mortality), Reproducibility of Results, Seroepidemiologic Studies.
- MESH :
- chemical : Antibodies, Viral.
- geographic , epidemiology : China, Italy.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- immunology : Betacoronavirus.
- mortality : Coronavirus Infections, Pneumonia, Viral.
- pathogenicity : Betacoronavirus.
- Adaptive Immunity, Clinical Laboratory Techniques, Epidemiological Monitoring, Health Services Accessibility, Humans, Mortality, Pandemics, Reproducibility of Results, Seroepidemiologic Studies.
Abstract
COVID-19 case fatalities surged during the month of March 2020 in Italy, reaching over 10,000 by 28 March 2020. This number exceeds the number of fatalities in China (3,301) recorded from January to March, even though the number of diagnosed cases was similar (85,000 Italy vs. 80,000 China). Case Fatality Rates (CFR) could be somewhat unreliable because the estimation of total case numbers is limited by several factors, including insufficient testing and limitations in test kits and materials, such as NP swabs and PPE for testers. Sero prevalence of SARS-CoV-2 antibodies may help in more accurate estimations of the total number of cases. Nevertheless, the disparity in the differences in the total number of fatalities between Italy and China suggests investigation into several factors, such as demographics, sociological interactions, availability of medical equipment (ICU beds and PPE), variants in immune proteins (e.g., HLA, IFNs), past immunity to related CoVs, and mutations in SARS-CoV-2, could impact survival of severe COVID-19 illness survival and the number of case fatalities.
DOI: 10.3855/jidc.12734
PubMed: 32235086
Affiliations:
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Le document en format XML
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This number exceeds the number of fatalities in China (3,301) recorded from January to March, even though the number of diagnosed cases was similar (85,000 Italy vs. 80,000 China). Case Fatality Rates (CFR) could be somewhat unreliable because the estimation of total case numbers is limited by several factors, including insufficient testing and limitations in test kits and materials, such as NP swabs and PPE for testers. Sero prevalence of SARS-CoV-2 antibodies may help in more accurate estimations of the total number of cases. Nevertheless, the disparity in the differences in the total number of fatalities between Italy and China suggests investigation into several factors, such as demographics, sociological interactions, availability of medical equipment (ICU beds and PPE), variants in immune proteins (e.g., HLA, IFNs), past immunity to related CoVs, and mutations in SARS-CoV-2, could impact survival of severe COVID-19 illness survival and the number of case fatalities.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Espagne</li><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Rubino, Salvatore" sort="Rubino, Salvatore" uniqKey="Rubino S" first="Salvatore" last="Rubino">Salvatore Rubino</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Kelvin, Nikki" sort="Kelvin, Nikki" uniqKey="Kelvin N" first="Nikki" last="Kelvin">Nikki Kelvin</name></noRegion><name sortKey="Kelvin, David" sort="Kelvin, David" uniqKey="Kelvin D" first="David" last="Kelvin">David Kelvin</name></country><country name="Espagne"><noRegion><name sortKey="Bermejo Martin, Jesus F" sort="Bermejo Martin, Jesus F" uniqKey="Bermejo Martin J" first="Jesús F" last="Bermejo-Martin">Jesús F. 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